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NEW YORK-PRSBYTERIAN/COLUMBIA UNIVERSITY MEDICAL CENTER


Interstitial Lung Disease Program
Nina Patel, M.D.For Appointments
NewYork-Presbyterian/Columbia University Medical Center
161 Fort Washington Avenue
Herbert Irving Pavilion 321A
New  York, NY 10032
P:  (212) 305-8203
F:  (212) 305-8426


NewYork-Presbyterian/Columbia University Medical Center offers a multidisciplinary program  that optimizes the care of patients with many types of interstitial lung  disease (ILD) including:Idiopathic pulmonary fibrosisNonspecific interstitial  pneumonitisHypersensitivity pneumonitisILD related to connective tissue  diseases (such as lupus)PneumoconiosisDrug-induced ILDOur  program features a team of specialists—including pulmonologists, thoracic  surgeons, radiologists, a chest pathologist, pulmonary rehabilitation specialists,  and a rheumatologist—who perform a detailed evaluation of each patient and  tailor an individualized plan of care. That plan may include supportive  therapy, medications, clinical research studies of new agents, and referral for  lung transplantation when necessary.The  ILD team works closely with NewYork-Presbyterian Hospital’s renowned lung  transplantation program for eligible patients in whom drug treatment has  failed. Our team also evaluates patients for concurrent (and potentially treatable)  pulmonary conditions (such as chronic obstructive pulmonary disease, sleep  apnea, and deconditioning) to improve their overall lung health.FormsDownload the ILD patient referral form.Our ServicesLung biopsy showing normal lung tissue, with a healthy interstitThe  ILD team at NewYork-Presbyterian/Columbia University Medical Center offers the following  services for patients with interstitial lung disease:Diagnostic evaluation using a       number of approaches (including advanced imaging, bronchoscopy, and/or       surgical lung biopsy, as appropriate) and multidisciplinary case reviewCreation of a personalized       treatment plan (which may include conventional or novel therapies)Pulmonary rehabilitationManagement of coexisting pulmonary       conditions (such as chronic obstructive pulmonary disease or obstructive       sleep apnea)Evaluation for and consideration of       lung transplantation in eligible patientsEvaluation for and enrollment in       novel research and investigational treatment studies for eligible patients

EXCITING ADVANCEMENTS - DR. HANS-WILEM SNOECK, CUMC


New Lung “Organoids” In a Dish Mimic Features of Full-Size Lung"Mini organs" may aid in understanding, treating respiratory diseasesMay 11, 2017 Posted in: Immunology, Infectious Diseases, Pulmonary, Research /   New lung “organoids”—tiny 3-D structures that mimic features of a full-sized lung—have been created from human pluripotent stem cells by researchers at Columbia University Medical Center (CUMC). The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.A paper detailing the discovery was published in the April 24 online issue of Nature Cell Biology.Organoids are 3-D structures containing multiple cell types that look and function like a full-sized organ. By reproducing an organ in a dish, researchers hope to develop better models of human diseases and find new ways of testing drugs and regenerating damaged tissue.“Researchers have taken up the challenge of creating organoids to help us understand and treat a variety of diseases,” said Hans-Willem Snoeck, PhD, professor of medicine (in microbiology & immunology) at Columbia and lead investigator of the study. “But we have been tested by our limited ability to create organoids that can replicate key features of human disease.”The lung organoids created in Dr. Snoeck’s lab are the first to include branching airway and alveolar structures, similar to human lungs.To demonstrate the functionality of the organoids, the researchers showed that the organoids reacted in much the same way as a real lung does when infected with respiratory syncytial virus (RSV). Additional experiments revealed that the organoids also responded as a human lung would when carrying a gene mutation linked to pulmonary fibrosis.RSV is a major cause of lower respiratory tract infection in infants and has no vaccine or effective antiviral therapy. Idiopathic pulmonary fibrosis, a condition that causes scarring in the lungs, causes 30,000 to 40,000 deaths in the United States each year. A lung transplant is the only cure for this condition.“Organoids, created with human pluripotent or genome-edited embryonic stem cells, may be the best, and perhaps only, way to gain insight into the pathogenesis of these diseases,” Dr. Snoeck says. AboutThe paper is titled “A three-dimensional model of human lung development and disease from pluripotent stem cells.” Additional authors (also from Columbia University Medical Center) are Ya-Wen Chen, Sarah Xuelian Huang, Ana Luisa Rodrigues Toste de Carvalho, Siu-Hong Ho, Mohammad Naimul Islam, Jahar Bhattacharya, Laura M. Palermo, Matteo Porotto, and Anne Moscona. The authors declare no competing financial interests. This work was supported by the NIH (grants HL120046-01, 1U01HL134760-01, RO1 AI031971, and RO1 AI114736), a sponsored research agreement from Northern Biologics Inc., and funding from the Thomas R Kully IPF Research Fund. Columbia University Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. The campus that Columbia University Medical Center shares with its hospital partner, NewYork-Presbyterian, is now called the Columbia University Irving Medical Center.  For more information, visit cumc.columbia.edu or columbiadoctors.org.